Design of Experiments for iterated high throughput screening

We have established that the problem of designing experiments for iterated high throughput experiments requires the specification of each generation of experiments, given information the previous generations.  We will denote each generation of experiments as pastedgraphic-9_textmedium.  The problem is how to specify pastedgraphic-10_textmedium as a function of pastedgraphic-12_textmedium.  


Below, we describe the classical approach, and modern alternatives, finishing with the current state of the art, developed in PACE: model-based evolutionary design of experiments.