The left framed roadmap schemes integrate simple chemical metabolism, encapsulation and genetic systems first pairwise and then as a triple. PACE is well on its way to completing the middle row of these roadmaps.
The shown overview (lower image) summarize our microfluidic activities in PACE. BioMIP has provided a large number of microfluidic environments for experiments regarding monitoring protocells to the PACE Partners.
In the 1st year of the project we have further developed the Chemical microprocessor (ChµP) - a hybrid and electronic programmable BioMEMS-Chip and a few microsystems helping to understand and analyzing artificial microcompartments based on o/w and w/o droplet systems.
In the 1st and 2nd Year of the project we started to fabricate and successfully test devices for electronic control of vesicles and liposomes. Furthermore we designed, fabricated and tested microreactors for monitoring amplification reactions, which produces stationary waves.
In 2nd and 3th year of the project we realized gradient microfluidic devices for phase diagram screening of vesicles but also artificial µ-fluidic electronic cells based on electroosmotic controlled artificial membranes. Recent results are involved with significant progress in proof-of-principle experiments on regulated amplification and combining chemical self-replication and metabolism/containment.