Milestones and Deliverables

Milestones

1.1      The use of electrogenerated pH jumps for the separation of duplex oligonucleotide structures.

1.2      Design of an electrocatalytic electrode for the ligation of sulfhydryl groups to disulfides.

Deliverables

1.1      An electrochemical method for the separation of oligonucleotide duplex structures through pH jumps.

1.2      An electrocatalytic electrode for the ligation of sulfhydryl-functionalized oligonucleotide fragments.